Astrocytes and Epilepsy by Jacqueline A. Hubbard, Devin K. Binder

By Jacqueline A. Hubbard, Devin K. Binder

Epilepsy is a devastating workforce of neurological problems characterised by means of periodic and unpredictable seizure task within the mind. there's a serious desire for brand spanking new medicines and techniques given than at the very least one-third of all epilepsy sufferers aren't made freed from seizures via present medicines and develop into "medically refractory". a lot of epilepsy learn has fascinated with neuronal healing ambitions, yet present antiepileptic medications usually reason critical cognitive, developmental, and behavioral unintended effects. contemporary findings point out a severe contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure task. moreover, many very important mobile and molecular adjustments ensue in astrocytes in epileptic tissue in either people and animal versions of epilepsy. The aim of Astrocytes and Epilepsy is to comprehensively evaluation interesting findings linking alterations in astrocytes to practical adjustments accountable for epilepsy for the 1st time in booklet layout. those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may well signify an immense new healing objective within the keep watch over of epilepsy.

Astrocytes and Epilepsy comprises history explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and proof from either human tissue experiences and animal types linking useful adjustments in astrocytes to epilepsy. fantastically labelled diagrams are awarded and correct figures from the literature are reproduced to clarify key findings and ideas during this speedily rising box. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking good care of sufferers with epilepsy.

  • Presents the 1st accomplished e-book to synthesize old and up to date learn on astrocytes and epilepsy into one coherent volume
  • Provides a superb source at the box of astrocyte biology and astrocyte-neuron interactions
  • Details capability healing goals, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

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197–222. Given the morphological and functional heterogeneity of astrocytes, identification of “classical” astrocytes requires careful consideration. Kimelberg put forth the following criteria [14,15]: 1. Absence of electrical excitability 2. Very negative membrane potential (−80 to −90 mV) 3. Expression of neurotransmitter transporters (GABA, glutamate) 4. 4 Morphological diversity of astrocytes. Ia, pial tanycyte; Ib, vascular tanycyte; II, radial astrocyte (Bergmann glial cell); III, marginal astrocyte; IV, protoplasmic astrocyte; V, velate astrocyte; VI, fibrous astrocyte; VII, perivascular astrocyte; VIII, interlaminar astrocyte; IX, immature astrocyte; X, ependymocyte; XI, choroid plexus cell.

24] Todd RB. The descriptive and physiological anatomy of the brain, spinal cord, and ganglions, and of their coverings, adapted for the use of students. London: Sherwood; 1845. [25] Binder DK, Rajneesh KF, Lee DJ, Reynolds EH. Robert Bentley Todd’s contribution to cell theory and the neuron doctrine. J Hist Neurosci 2011;20(2):123–34. [26] Todd RB, Bowman W. The physiological anatomy and physiology of man. London: Parker; 1856. [27] Guillery RW. Relating the neuron doctrine to the cell theory.

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