BCL‑2 Protein Family: Essential Regulators of Cell Death by Claudio Hetz

By Claudio Hetz

During this ebook, scientists pioneering the sector have compiled a chain of centred chapters to focus on the relevance of the BCL‑2 family members of proteins in apoptosis, body structure and illness. a huge concentration of this quantity is thinking about the aptitude TH period PEUT IC advantages of concentrating on apoptosis pathways within the context of human illness. Readers attracted to knowing how a mobile handles pressure and the implications of dysregulation of this technique for human ailment will locate this publication very priceless. It makes an attempt to explain a desirable region of study the place body structure and biomedicine converge at diverse degrees, revealing a visit from the molecular rules of apoptosis to the influence of this method to the body structure of a complete organism.

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Extra info for BCL‑2 Protein Family: Essential Regulators of Cell Death (Advances in Experimental Medicine and Biology)

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Nat Cell Biol 2007; 9(5):550-555. 11. Malia TJ, Wagner G. NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL. Biochemistry 2007; 46(2):514-525. 12. Shimizu S, Narita M, Tsujimoto Y. BCL-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 1999; 399(6735):483-487. 24 BCL-2 Protein Family 13. Vander Heiden MG, Li XX, Gottleib E et al. Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane.

45. Scorrano L, Oakes SA, Opferman JT et al. BAX and BAK regulation of endoplasmic reticulum Ca2 : a control point for apoptosis. Science 2003; 300(5616):135-139. 46. Zong WX, Li C, Hatzivassiliou G et al. Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol 2003; 162(1):59-69. 47. Baffy G, Miyashita T, Williamson JR et al. Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced BCL-2 oncoprotein production.

Geng J, Klionsky DJ. The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein modifications: beyond the usual suspects’ review series. EMBO Rep 2008; 9(9):859-864. 150. Lum JJ, DeBerardinis RJ, Thompson CB. Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol 2005; 6(6):439-448. 151. Sarbassov DD, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol 2005; 17(6):596-603. Homeostatic Functions of BCL-2 Proteins beyond Apoptosis 29 152.

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