Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide by Philip K. Moore, Matt Whiteman

By Philip K. Moore, Matt Whiteman

This ebook places hydrogen sulfide in context with different gaseous mediators corresponding to nitric oxide and carbon monoxide, stories the to be had mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a large choice of disorder states. Hydrogen sulfide has lately been stumbled on to be a clearly happening gaseous mediator within the physique. Over a comparatively brief time period this evanescent fuel has been printed to play key roles in more than a few physiological techniques together with regulate of blood vessel quality and therefore blood strain and within the rules of nerve functionality either within the mind and the outer edge. problems in regards to the biosynthesis or job of hydrogen sulfide can also predispose the physique to illness states resembling irritation, cardiovascular and neurological problems. curiosity during this novel gasoline has been excessive in recent times and plenty of examine teams world wide have defined its person organic results. additionally, medicinal chemists are starting to synthesize novel natural molecules that unencumber this gasoline at outlined premiums that allows you to exploiting those new compounds for healing profit.

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Extra resources for Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide (Handbook of Experimental Pharmacology)

Sample text

1 Enzymatic Generation of Persulfides . . . . . . . . . . . . . . . . . . . . . . . . . 2 Direct Nonenzymatic Generation of Persulfides by H2S . . . . . . . . . . . . . . . 1 Reaction with Sulfenic Acids . . . . . . . . . . . . . . . . . . . . . . . . . 2 Reaction with S-Nitrosothiols . . . . . . . . . . . . . . . . . . . . . . . . . 3 Reaction with Disulfides . . . .

The adduct of persulfide and Cy5-maleimide is a disulfide that will be cleaved by the DTT leading to a decrease of the in-gel fluorescence signal in the samples containing persulfides. This method has its advantage of being relatively simple and available to every researcher (because the reagents are commercially available). The only limitation of the method is that it does not offer actual persulfide labelling which would allow wide proteomic analysis. Particular care should be taken to ensure that all thiols and persulfides are indeed blocked in the initial step, as that is the crucial step for the subsequent data interpretation.

1 Reaction with Sulfenic Acids . . . . . . . . . . . . . . . . . . . . . . . . . 2 Reaction with S-Nitrosothiols . . . . . . . . . . . . . . . . . . . . . . . . . 3 Reaction with Disulfides . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Nonenzymatic S-sulfhydration by Species Originating from H2S . . . . . . . . . . 1 Reaction with Polysulfides . . . . . . . . . . . . . .

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