Electrocardiographic assessment of repolarization by Bart Hooft van Huysduynen

By Bart Hooft van Huysduynen

The electrocardiographic evaluate of repolarization heterogeneity. The time period repolarization heterogeneity refers to ameliorations in repolarization instants within the center. mostly, repolarization within the human center is a comparatively delicate, non-stop approach, within which adjoining parts repolarize virtually concurrently. a number of medicinal drugs or cardiac illnesses may possibly disturb the repolarization and therefore elevate the repolarization heterogeneity, which predisposes to arrhythmias. A non-invasive index in a position to check this repolarization heterogeneity might have nice scientific worth. the traditional 12-lead electrocardiogram (ECG) is beautiful for this goal because it is regularly occurring and displays repolarization heterogeneity: the morphology and period of the T wave within the ECG rely on changes within the repolarization instants of the ventricular myocardial cells. the precise development of the conventional repolarization within the human middle continues to be now not accurately recognized. a number of mapping and vectorcardiographic experiences recommend that transmural (perpendicular to the myocardial wall) and paramural (along the ventricular partitions) repolarization changes make sure the traditional morphology of the T-wave. diversified electrocardiographic measures of T-wave morphology replicate diversified features of cardiac repolarization, which defines their suitability to evaluate repolarization heterogeneity, as largely mentioned during this bankruptcy

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18. Downar E, Janse MJ, Durrer D. The effect of “ischemic” blood on transmembrane potentials of normal porcine ventricular myocardium. Circulation. 1977;55:455462. 34 Introduction: Electrocardiographic assessment of repolarization heterogeneity 19. Franz MR. Long-term recording of monophasic action potentials from human endocardium. Am J Cardiol. 1983;51:1629-1634. 20. Haws CW, Lux RL. Correlation between in vivo transmembrane action potential durations and activation-recovery intervals from electrograms.

We use an interactive ECG analysis program to accurately measure the QRS duration before and a half year after surgery. Changes in right ventricular end-diastolic volumes were previously studied with cardiac magnetic resonance imaging and are incorporated in the present study. In chapter 6 we extend the analysis of the Fallot patients with electrocardiographic indices proposed to measure repolarization heterogeneity. We measure the changes in these indices due to pulmonary valve replacement and study the possible relation with arrhythmias.

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