Industrial Biotransformations by Andreas Liese, Karsten Seelbach, Christian Wandrey

By Andreas Liese, Karsten Seelbach, Christian Wandrey

The thoroughly revised moment version of this straightforward and application-oriented review of one-step biotransformations of business value.
in line with vast literature and patent examine, this publication is exclusive in arranging each one strategy in a scientific approach to enable for simple comparability. all of the chapters were rewritten, with the entire approaches up-to-date and greater than 30 new strategies further. each one set of information is observed by way of key literature citations, supported by way of movement sheets the place on hand, lowered to their major components. furthermore, an in depth index categorised via substrates, items, enzymes, and firms presents direct entry to every strategy, geared up in line with enzyme classification. Biotechnologists, biochemists, microbiologists, strategy engineers and people operating within the chemical and biotechnological industries will locate right here the entire major parameters characterizing either the biotransformation and the method.

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Hydrolases hydrolysis reactions 4. Lyases group elimination (forming double bonds) 5. Isomerases isomerization reactions 6. Ligases bond formation coupled with a triphospate cleavage As the systematic name may be very extensive and uncomfortable to use, the Enzyme Commission (EC) has also developed a numeric system based on the same criteria, which can be used together with the recommended name to specify the mentioned enzyme. According to this system, each enzyme is assigned a fourdigit EC number (Table 2).

190, Cambridge Univ. , (1980) Immobilized Enzymes. , Wandrey, C. , Crosby, J. ), pp. , Wandrey, C. (1993) Continuous processes with soluble enzymes, Ind. J. J. (1979) Glucose isomerase production of high-fructose syrups, in: Appl. Biochem. Bioeng. , Goldstein, L. ) pp. 97±207, Academic Press, New York References 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. 70. 71. 72. 73. (1998) 687 days is the record for Sweetzyme T, BioTimes, Novo Nordisk, 1/98. , (1979) Industrial application of fiber-entrapped enzymes, in: Appl.

9 Acting on phosphorous-nitrogen bonds O HO P O H2O NHR HO P OH OH NH2R + OH R = organic residue The only enzyme classified under this subclass is phosphoamidase. 10 Acting on sulfur-nitrogen bonds S H2O NR2 S OH + HNR2 S = sulfon group R = organic residue There is only one subdivision of this subclass. 11 Acting on carbon-phosphorous bonds O HO P O O Cn H2O HO P R OH O OH + H Cn R OH R = CH3, OH n = 0, 1 If n = 0, the product is an aldehyde. 12 Acting on sulfur-sulfur bonds S1 S2 H2O S1 OH + HS S2 S1 = sulfate S2 = thiosulfate The only enzyme classified under this subclass is trithionate hydrolase.

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