Inflammation and Oxidative Stress in Neurological Disorders: by Akhlaq A. Farooqui

By Akhlaq A. Farooqui

This publication offers readers with leading edge and entire details at the influence of nutrition, workout and sleep on neuroinflammation and oxidative tension in common brains and brains from sufferers with neurological problems.

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Another important feature of the ketogenic diet is the decrease in glycolytic flux resulting in decrease in blood glucose. It is interesting to note that 2-Deoxy-d-glucose (2DG), an analog of glucose that inhibits phosphoglucose isomerase and hence inhibits glycolysis, blocks epileptogenesis in the rat kindling model by decreasing the expression of BDNF and its principal receptor, tyrosine kinase B (TrkB; Garriga-Canut et al. 2006) supporting the view that ketogenic diet produces beneficial effects in neurological disorders.

Thus, phytochemicals containing foods such as flavonoids in blueberries, catechins in green tea, and curcumin in turmeric increase multiple parameters of hippocampal synaptic plasticity, and these parameters correlated with improvements in spatial memory (Casadesus et al. 2004; Farooqui 2012). Mitochondria are a major source of ROS in the neural cells and dietary restriction directly reduce the generation of ROS by minimizing proton leakage (Hagopian et al. 2005; Civitarese et al. 2007; Bevilacqua et al.

J Clin Invest 113:106–114 Bonda DJ, Lee HG, Camins A, Pallas M, Casadesus G, Smith MA, Zhu X (2011) The sirtuin pathway in aging and Alzheimer disease: mechanistic and therapeutic considerations. Lancet Neurol 10:275–279 References 31 Bori Z, Zhao Z, Koltai E, Fatouros IG, Jamurtas AZ, Douroudos II, Terzis G, Chatzinikolaou A, Sovatzidis A, Draganidis D, Boldogh I, Radak Z (2012) The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle.

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