Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents by Paul J. Smith, Eddy W. Yue

By Paul J. Smith, Eddy W. Yue

One of many few books to hide all features of cyclin-dependent kinases (CDKs), Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents presents an outline of CDKs as molecular and practical entities, their involvement in several disorder tactics, and their power for pharmacological modulation. With contributions from the pinnacle overseas researchers within the box, the e-book takes a latest method of research the significance of rational drug layout and knowledge-based therapeutics relating to CDKs.

The first sections of the ebook talk about the mixing of telephone cycle keep watch over pathways, possibilities for concentrating on, pursuits of inhibitors, and the assessment of CDK inhibitors, exploring subject matters corresponding to the in vivo function of CDKs in general homeostasisand tumor improvement and the structural biology of CDKs. The 3rd part examines the layout, improvement, and chemistry of small molecule CDK inhibitors, with discussions starting from the early-stage discovery of recent chemical entities with a capability to inhibit CDKs to late-stage compounds in medical improvement. the ultimate part assesses the present prestige of CDK inhibitors in scientific trials, the healing deployment demanding situations of small molecule inhibitors, and the long run improvement of CDK inhibitors as anticancer brokers.

The box of drug improvement is at a serious aspect by way of figuring out the provision, benefits, and downsides of CDKs as healing ambitions for small molecules. supplying the main up to date, in-depth insurance on hand in one quantity, Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents surveys the luck of the brokers built so far, the potential for new routes to extra selective inhibitors, and the transforming into appreciation of severe, healing issues.

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Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents (Enzyme Inhibitors Series)

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