Introduction to the Blood-Brain Barrier: Methodology, by William M. Pardridge MD

By William M. Pardridge MD

Wisdom of the blood-brain barrier varieties a vital part within the realizing of a big percentage of clinical disciplines. however, lack of knowledge during this box nonetheless impedes growth in lots of components, together with cerebrovascular illness, Alzheimer's illness, cerebral AIDS, mind tumors, and the advance of potent new neuropharmaceuticals. This creation for either researchers and clinicians around the clinical sciences is meant to help either these starting paintings at once during this quarter and people wishing just to be higher proficient whilst analyzing info the place the blood-brain barrier might be concerned. fresh advances in either technique and biology are exact in fifty state of the art chapters written by means of overseas experts.

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1994). Measurement of blood-brain barrier GLUTl glucose transporter and actin mRNA by a quantitative polymerase chain reaction assay. J. , 62, 2085-90. Boado, R. , Wang, L. and Pardridge, W. M. (1994). Enhanced expression of the blood-brain barrier GLUTl glucose transporter gene by brain-derived factors. , 22, 259-67. Cornford, E. M. (1985). The blood-brain barrier, a dynamic regulatory interface. MoL PhysioL, 7, 219-60. Cornford, E. , Diep, C. P. and Pardridge, W. M. (1985). Blood-brain barrier transport of valproic acid.

H. E. Himwich, pp. 163-80. New York: Spectrum Publications. Oldendorf, W. H. (1977). The blood-brain barrier. In The Ocular and Cerebral Spinal Fluids, ed. L. Z. Bito, H. Davson and J. D. Fenstermacher. ), pp. 177-90. Oldendorf, W. H. (1981). Clearance of radiolabeled substances by brain after arterial injection using a diffusible internal standard. In Research Methods in Neurochemistry, ed N. Marks and R. Rodnight, pp. 91-112. New York: Plenum Publishing. 22 Oldendorf, W. H. and Braun, L. D. (1976).

Exp. , 239, 724-9. Yudilevich, D. L. and De Rose, N. (1971). Blood-brain transfer of glucose and other molecules measured by rapid indicator dilution. Am. J. PhysioL, 220, 841-6. , Oldendorf, W. , Geller, E. and Braun, L. (1977). Effect of albumin binding and amino acid competition on tryptophan uptake into brain. J. , 28, 1015-23. 23 3 Development of Brain Efflux Index (BEI) method and its application to the blood-brain barrier efflux transport study TETSUYA TERASAKI Introduction Theory Methods Development BBB efflux transport system Introduction Brain interstitial fluid concentration of drugs and/or nutrients, a significantly important value for the central nervous system (CNS) effects and/or the cerebral functions, is believed to be mainly governed by the net flux between the brain interstitial fluid and the circulating blood in the brain capillaries across the blood-brain barrier (BBB).

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