Oncogenes Meet Metabolism: From Deregulated Genes to a by P. Rustin, G. Kroemer (auth.), G. Kroemer, D. Mumberg, H.

By P. Rustin, G. Kroemer (auth.), G. Kroemer, D. Mumberg, H. Keun, B. Riefke, T. Steger-Hartmann, K. Petersen (eds.)

In Nineteen Twenties, Otto Warburg defined the phenomenon of ‘aerobic glycolysis’, the power of tumour cells to transform glucose to lactate within the presence of standard oxygen stipulations. Warburg’s speculation of an altered metabolism in melanoma cells stumbled on no speedy reputation, even though it used to be latter proven for many human tumours. With the appearance of molecular biology the point of interest in tumour learn has shifted in the direction of the hunt for oncogenes. in spite of the fact that, the curiosity in melanoma molecular profiling ultimately ended in a renaissance of the Warburg influence attempting to mix genetic adjustments with results on metabolism with the aid of smooth analytic applied sciences to swiftly learn vast forms of metabolites in a variety of tissues and bodyfluids (metabonomics).

Show description

Read or Download Oncogenes Meet Metabolism: From Deregulated Genes to a Broader Understanding of Tumour Physiology PDF

Similar physiology books

Neuroendocrinology in Physiology and Medicine

In Neuroendocrinology in body structure and medication, Michael Conn and Marc Freeman have introduced jointly a panel of best specialists to create a finished, built-in remedy of the techniques in which the mind acts as an endocrine organ not just to manage hormonal services, but in addition to keep up homeostasis and keep an eye on habit.

Functional Dairy Products, Volume 2

Drawing at the services of a exotic panel of specialists, sensible Dairy items: quantity 2 studies the newest advancements within the box and their commercial purposes. It outlines the wellbeing and fitness merits of sensible dairy items and their purposes in components comparable to weight administration, baby health and wellbeing, and intestine well-being.

Extra resources for Oncogenes Meet Metabolism: From Deregulated Genes to a Broader Understanding of Tumour Physiology

Sample text

Future studies will elucidate which among these links, if any, has a preponderant impact on oncogenesis or tumor progression. Similarly, future work will determine whether dual therapeutic interventions that might simultaneously restore apoptosis and target the metabolic alterations linked to cancer might provide valid tools for our combat against cancer. Acknowledgements. G. Kroemer is supported by Ligue Nationale Contre le Cancer (équipe labellisée), the European Union (Active p53, ChemoRes, DeathTrain, TransDeath, RIGHT), Cancéropôle Ile-de-France, Institut National du Cancer, and the Agence Nationale pour la Recherche.

HIF is also able to attenuate mitochondrial respiration through the induction of pyruvate dehydrogenase kinase 1 (PDK1), which in part accounts for the Warburg effect that describes the propensity for cancers to avidly take up glucose and convert it to lactate with the concurrent decrease in mitochondrial respiration. V. Dang HIF and MYC, such as PDK1, LDHA, HK2, and TFRC, are therefore attractive therapeutic targets, because their coordinate induction by HIF and MYC widens the therapeutic window between cancer and normal tissues.

Future studies will elucidate which among these links, if any, has a preponderant impact on oncogenesis or tumor progression. Similarly, future work will determine whether dual therapeutic interventions that might simultaneously restore apoptosis and target the metabolic alterations linked to cancer might provide valid tools for our combat against cancer. Acknowledgements. G. Kroemer is supported by Ligue Nationale Contre le Cancer (équipe labellisée), the European Union (Active p53, ChemoRes, DeathTrain, TransDeath, RIGHT), Cancéropôle Ile-de-France, Institut National du Cancer, and the Agence Nationale pour la Recherche.

Download PDF sample

Rated 4.43 of 5 – based on 33 votes