By Klaus Ley (auth.), Klaus Ley M.D. (eds.)
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1998). In contrast to extravasation, few details are available about movements of cells within hematopoietic organs. The beginnings of a conceptual framework for how hematopoietic cells may navigate in complex environments containing many stimuli, such as bone marrow, have been advanced in an elegant study by Foxman et ai. (1997). In that study, neutrophils were found capable of serially responding to multiple chemotactic factors, even in the presence of disorienting concentrations of chemotactic factors, which they had very recently responded to by migrating.
Homing of Transplanted HSC: Effect of the Cell Cycle As mentioned previously, HSC must home to proper microenvironments following clinical HSC transplantation. When used to support high-dose chemotherapy and/or radiotherapy in cancer treatment, the bone marrow is conditioned by lethal ablation and the patient will die if engraftment fails. It is therefore considered of primary importance to understand the molecular mechanisms of HSC homing and engraftment following transplantation. Formation and Differentiation of Leukocytes 37 Perhaps surprisingly, a key factor in predicting whether or not HSC can engraft successfully is position in the cell cycle at the time of transplantation.
1994), but may not be expressed by fetal liver HSC (Huang and Auerbach, 1993). HA, a disaccharide polymer consisting of repeat units of N-acetyl-D-glucosamine and Nacetyl-D-glucuronic acid, is ubiquitous in extracellular matrix (ECM) and in circulation. , 1997). , 1998). , 1990). However, antibody studies can be confounded by toxicity or other effects of the antibody itself, and the relevance of in vitro assays to in vivo biology must of course always be tested. Indeed, in the case of CD44, data from work done with knockout mice are not easily reconciled with the in vitro data.