Physiology of the Kidney and of Water Balance (Springer by P. Deetjen, J.W. Boylan, K. Kramer, R.V. Coxon

By P. Deetjen, J.W. Boylan, K. Kramer, R.V. Coxon

This little publication used to be assembled from the authors' lectures to clinical scholars and used to be initially released as one quantity within the sequence Human body structure, edited via O. H. Gauer, ok. Kramer, and R. Jung. The editors meant that every quantity during this sequence be self sustaining of the others and we have now saved to this function. now we have incorporated right here simply fabric that we think is critical for scientific scholars to understand so that it will comprehend kidney functionality in future health and, by means of later extrapolation, in illness. The contents relaxation on authorised ideas estab­ lished by means of experiments, and little area is given to what's debatable, hypo­ thetical, or unresolved. we're happy that Dr. Coxon has been prompted to arrange an English language model of this article. we are hoping that it'll function a prepared reference and overview resource for the beleaguered clinical pupil. P. Deetjen J. W. Boylan ok.

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Example text

Transport out of the cell into the interstitium is, however, favored by the electrical gradient. Broken arrows indicate passive movement. Hydrogen Ion Transport Secretion of Hydrogen Ions. Tubular cells along the entire length of the nephron and collecting ducts are apparently capable of secreting hydrogen ions, as is illustrated in Fig. 28. In the experiment on which this figure is based, pH was measured in samples obtained by micropuncture from proximal and distal convolutions of nondiuretic rats and in the bladder urine (34).

12 meq per day. Since there exists a potential difference between the inside of the proximal tubular cells and both the luminal fluid and the interstitial fluid (Fig. 27), the transport of protons must take place against an electrical gradient. 75. Although reliable direct Physiology of Kidney and of Water Balance 53 measurements of intraceIlular pH are not available, this calculated value is improbably low. One must therefore presume that the secretion of H+ is a case of active transport. The same considerations that have been advanced with regard to the proximal tubule are equally valid for the distal segments, and more especially for the coIlecting ducts.

By manipulation of the arterial blood supply, the GFR, and hence the sodium load presented to the tubules, was varied. Further variations in sodium reabsorption were induced by saline infusions and by partial inhibition of active transport by pharmacological agents or by oxygen deprivation. As the rate of sodium reabsorption falls, there is a proportionate reduction in oxygen consumption until, with the cessation of net reabsorption of sodium- that is, in a nonfiltering kidneya basal level of oxygen consumption is reached.

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