Re-Evaluation of Some Organic Chemicals, Hydrazine and by International Agency for Research on Cancer Staff

By International Agency for Research on Cancer Staff

Offers re-evaluations of the carcinogenic hazards to people posed by way of publicity to a couple 121 natural compounds, often business chemical substances, chosen from one of the 834 brokers evaluated in volumes 1-70 of the IARC Monographs sequence. chemical compounds have been chosen for second look at the foundation of substantial new proof that would demand a metamorphosis within the IARC type of carcinogenic risk.The reviews are awarded in 3 elements. half one presents complete checks of all proper facts on experimental carcinogenesis and melanoma epidemiology for 4 chemical compounds: acrylonitrile 1 3-butadiene, chloroprene, and dichloromethane. of those, 1 3-butadiene remained categorized as most likely carcinogenic to people, and dichloromethane remained categorised as potentially carcinogenic to people. Acrylonitrile, formerly categorised as most likely carcinogenic to people, was once reclassified as almost certainly carcinogenic. For chloroprene, formerly judged no longer classifiable, new epidemiological facts and new bioassays demonstrating carcinogenicity in rats and mice supported class as in all probability carcinogenic to humans.Part re-evaluates 30 compounds for which new epidemiological or experimental carcinogenicity facts have been on hand and for which alterations in category have been expected. half 3 offers short updates for seventy six compounds and teams of compounds for which new proof used to be constrained to experimental carcinogenicity facts. As no new epidemiological proof used to be to be had, and no reclassification used to be expected, those monographs reproduce the former precis reviews and replace those with descriptions of recent information.

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K. D. Brunnemann, B. Dodet & D. Hoffmann (1987) Vol. 10. Benzene and Alkylated Benzenes (IARC Scientific Publications No. 85). Edited by L. K. O’Neill (1988) Vol. 11. Polychlorinated Dioxins and Dibenzofurans (IARC Scientific Publications No. 108). Edited by C. R. Buser, B. K. O’Neill (1991) Vol. 12. Indoor Air (IARC Scientific Publications No. 109). Edited by B. Seifert, H. van de Wiel, B. K. O’Neill (1993) IARC (1979) Criteria to Select Chemicals for IARC Monographs (IARC intern. tech. Rep. No.

47) × ppm, assuming a temperature of 25°C and a pressure of 101 kPa ACRYLONITRILE 45 Exposure to acrylonitrile can be determined by measuring parent acrylonitrile, acrylonitrile metabolites, and adducts. Acrylonitrile metabolites have been measured in blood and urine, but, except for measurement of thiocyanate, these methods have not been developed for routine monitoring of exposed humans (Agency for Toxic Substances and Disease Registry, 1990). 1 Production Acrylonitrile was first prepared in 1893 by dehydration of either acrylamide or ethylene cyanohydrin with phosphorus pentoxide (Fugate, 1963).

Schuller & L. Fishbein (1986) Vol. 9. Passive Smoking (IARC Scientific Publications No. 81). K. D. Brunnemann, B. Dodet & D. Hoffmann (1987) Vol. 10. Benzene and Alkylated Benzenes (IARC Scientific Publications No. 85). Edited by L. K. O’Neill (1988) Vol. 11. Polychlorinated Dioxins and Dibenzofurans (IARC Scientific Publications No. 108). Edited by C. R. Buser, B. K. O’Neill (1991) Vol. 12. Indoor Air (IARC Scientific Publications No. 109). Edited by B. Seifert, H. van de Wiel, B. K. O’Neill (1993) IARC (1979) Criteria to Select Chemicals for IARC Monographs (IARC intern.

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